The Zhou Laboratory 

Publications

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1. Zhou, B.#*, et al. (2024). Capillary aerocytes regulate lung alveolar regeneration following injury. (Manuscript under-review; #* First author, and co-corresponding author).

2. Zhou, B.#*, et al. (2024). Perivascular macrophages promote endothelial regeneration and lung repair in inflammatory injury. (Manuscript under-review; #* First author, and co-corresponding author).

3. Osorio-Valencia S, Zhou B*. Roles of Macrophages and Endothelial Cells and Their Crosstalk in Acute Lung Injury. Biomedicines. 2024; 12(3):632. (* corresponding author)

4. Huang, L.S., Anas, M., Xu, J., Zhou, B., Toth, P.T., Krishnan, Y., Di, A., and Malik, A.B. (2023). Endosomal trafficking of two-pore K(+) efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury. Elife 12. 10.7554/eLife.83842.

5. Zhou, B., Magana, L., Hong, Z., Huang, L.S., Chakraborty, S., Tsukasaki, Y., Huang, C., Wang, L., Di, A., Ganesh, B., et al. (2020). The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic-epigenetic reprogramming and resolves inflammatory injury. Nature Immunology 21, 1430-1443. 10.1038/s41590-020-0764-8.

6. Si, W.#, Zhou, B.#, Xie, W., Li, H., Li, K., Li, S., Deng, W., Shi, P., Yuan, C., Ke, T., et al. (2021). Angiogenic factor AGGF1 acts as a tumor suppressor by modulating p53 post-transcriptional modifications and stability via MDM2. Cancer Lett 497, 28-40. 10.1016/j.canlet.2020.10.014. (# equal contribution)

7. Liu, P., Wysocki, J., Souma, T., Ye, M., Ramirez, V., Zhou, B., Wilsbacher, L.D., Quaggin, S.E., Batlle, D., and Jin, J. (2018). Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation. Kidney Int 94, 114-125. 10.1016/j.kint.2018.01.029.

8. Zhou, B., Zeng, S., Li, N., Yu, L., Yang, G., Yang, Y., Zhang, X., Fang, M., Xia, J., and Xu, Y. (2017). Angiogenic factor with G Patch and FHA domains 1 (Aggf1) is a novel regulator of vascular injury. Arterioscler Thromb Vasc Biol 37, 675-684. 10.1161/ATVBAHA.117.308992.

9. Xu, W., Zeng, S., Li, M., Fan, Z., and Zhou, B*. (2017). Aggf1 attenuates hepatic inflammation and activation of hepatic stellate cells by repressing Ccl2 transcription. J Biomed Res 31, 428-436. 10.7555/JBR.30.20160046. (* Corresponding author)

10. Shao, J.#, Zeng, S.#, Zhou, B.#*, Xu, H., Bian, Y., and Xu, Y*. (2017). Angiogenic factor with G patch and FHA domains 1 (Aggf1) promotes hepatic steatosis in mice. Biochem Biophys Res Commun 482, 134-140. 10.1016/j.bbrc.2016.10.071. (#* Co-corresponding author and co-first author)

11. Zhou, B., Zeng, S., Li, L., Fan, Z., Tian, W., Li, M., Xu, H., Wu, X., Fang, M., and Xu, Y. (2016). Angiogenic factor with G patch and FHA domains 1 (Aggf1) regulates liver fibrosis by modulating TGF-beta signaling. Biochim Biophys Acta 1862, 1203-1213. 10.1016/j.bbadis.2016.02.002.

12. Zeng, S.#, Yang, Y.#, Cheng, X.#, Zhou, B.#, Li, P., Zhao, Y., Kong, X., and Xu, Y. (2016). HIC1 epigenetically represses CIITA transcription in B lymphocytes. Biochim Biophys Acta 1859, 1481-1489. 10.1016/j.bbagrm.2016.10.003.  (# equal contribution)

13. Tian, W., Fan, Z., Li, J., Hao, C., Li, M., Xu, H., Wu, X., Zhou, B., Zhang, L., Fang, M., and Xu, Y. (2016). Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-beta signaling. Int J Biochem Cell Biol 71, 35-43. 10.1016/j.biocel.2015.12.005.

14. Fang, M., Fan, Z., Tian, W., Zhao, Y., Li, P., Xu, H., Zhou, B., Zhang, L., Wu, X., and Xu, Y. (2016). HDAC4 mediates IFN-gamma induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells. Biochim Biophys Acta 1859, 294-305. 10.1016/j.bbagrm.2015.11.010.

15. Weng, X., Yu, L., Liang, P., Li, L., Dai, X., Zhou, B., Wu, X., Xu, H., Fang, M., Chen, Q., and Xu, Y. (2015). A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy. J Mol Cell Cardiol 82, 48-58. 10.1016/j.yjmcc.2015.02.010.

16. Weng, X., Yu, L., Liang, P., Chen, D., Cheng, X., Yang, Y., Li, L., Zhang, T., Zhou, B., Wu, X., et al. (2015). Endothelial MRTF-A mediates angiotensin II induced cardiac hypertrophy. J Mol Cell Cardiol 80, 23-33. 10.1016/j.yjmcc.2014.11.009.

17. Fan, Z., Hao, C., Li, M., Dai, X., Qin, H., Li, J., Xu, H., Wu, X., Zhang, L., Fang, M., Zhou, B., Tian, W., Xu Y. (2015). MKL1 is an epigenetic modulator of TGF-beta induced fibrogenesis. Biochim Biophys Acta 1849, 1219-1228. 10.1016/j.bbagrm.2015.07.013.

18. Cheng, X., Yang, Y., Fan, Z., Yu, L., Bai, H., Zhou, B., Wu, X., Xu, H., Fang, M., Shen, A., et al. (2015). MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription. Oncogene 34, 5570-5581. 10.1038/onc.2015.14.

19. Yang, Y., Cheng, X., Tian, W., Zhou, B., Wu, X., Xu, H., Fang, F., Fang, M., and Xu, Y. (2014). MRTF-A steers an epigenetic complex to activate endothelin-induced pro-inflammatory transcription in vascular smooth muscle cells. Nucleic Acids Res 42, 10460-10472. 10.1093/nar/gku776.

20. Xu, Y., Zhou, M., Wang, J., Zhao, Y., Li, S., Zhou, B., Su, Z., Xu, C., Xia, Y., Qian, H., et al. (2014). Role of microRNA-27a in down-regulation of angiogenic factor AGGF1 under hypoxia associated with high-grade bladder urothelial carcinoma. Biochim Biophys Acta 1842, 712-725. 10.1016/j.bbadis.2014.01.007.

21. Su, Z., Si, W., Li, L., Zhou, B., Li, X., Xu, Y., Xu, C., Jia, H., and Wang, Q.K. (2014). MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development. Int J Biochem Cell Biol 49, 53-63. 10.1016/j.biocel.2014.01.005.

22. Zhou, B., Si, W., Su, Z., Deng, W., Tu, X., and Wang, Q. (2013). Transcriptional activation of the Prox1 gene by HIF-1alpha and HIF-2alpha in response to hypoxia. FEBS Lett 587, 724-731. 10.1016/j.febslet.2013.01.053.

23. Zhou, B., Ma, R., Si, W., Li, S., Xu, Y., Tu, X., and Wang, Q. (2013). MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth. Cancer Lett 333, 159-169. 10.1016/j.canlet.2013.01.028.

24. Li, X., Huang, Y., Yin, D., Wang, D., Xu, C., Wang, F., Yang, Q., Wang, X., Li, S., Chen, S., Zhou, B., et al. (2013). Meta-analysis identifies robust association between SNP rs17465637 in MIA3 on chromosome 1q41 and coronary artery disease. Atherosclerosis 231, 136-140. 10.1016/j.atherosclerosis.2013.08.031.

25. Lu, Q., Yao, Y., Yao, Y., Liu, S., Huang, Y., Lu, S., Bai, Y., Zhou, B., Xu, Y., Li, L., et al. (2012). Angiogenic factor AGGF1 promotes therapeutic angiogenesis in a mouse limb ischemia model. PLoS One 7, e46998. 10.1371/journal.pone.0046998.

26. Zhou, B., Huang, C., Yang, J., Lu, J., Dong, Q., and Sun, L.Z. (2009). Preparation of heteroduplex enhanced green fluorescent protein plasmid for in vivo mismatch repair activity assay. Anal Biochem 388, 167-169. 10.1016/j.ab.2009.02.020.

27. Zhou, B., Dong, Q., Ma, R., Chen, Y., Yang, J., Sun, L.Z., and Huang, C. (2009). Rapid isolation of highly pure single-stranded DNA from phagemids. Anal Biochem 389, 177-179. 10.1016/j.ab.2009.03.044.